Join Barry Setlow as he discusses the behavioral and biological mechanisms of cost-benefit decision making in rodent models, with a focus on how substance use can affect variability and long-term consequences in decision making.

Nearly every aspect of life involves decisions between options that differ in both their expected rewards and the potential costs (such as delay to reward delivery or risk of harm) that accompany those rewards. The ability to choose adaptively when faced with such decisions is critical for well-being and overall quality of life; however, decision making is often compromised in neuropsychiatric conditions such as substance use disorders, which can prolong and exacerbate their severity and co-morbidities.

During this webinar, Dr. Barry Setlow will discuss research in rodent models investigating behavioral and biological mechanisms of cost-benefit decision making. In particular, he will focus on factors (including sex) that contribute to differences in cost-benefit decision making across the population, how variability in decision making is related to substance use, and how substance use can produce long-lasting alterations in decision making. It is hoped that a better understanding of these relationships may lead to new therapeutic approaches for neuropsychiatric conditions characterized by maladaptive decision making.

Key Topics Include:

  • Understand how different forms of cost-benefit decision making can be modeled in rats
  • Understand the contributions of gonadal hormones to sex differences in cost-benefit decision making
  • Understand the lasting effects of chronic cocaine on cost-benefit decision making


University of Florida

Barry Setlow, PhD is a Professor in the Department of Psychiatry at the University of Florida College of Medicine, and a member of the University of Florida Center for Addiction Research and Education. His lab uses rodent models to investigate the behavioral and neural mechanisms supporting cognitive and motivational functions, both in their normal operation and in models of various neuropsychiatric conditions. In particular, much of his research focuses on cost-benefit decision making, and how such decision making is altered in the context of drugs of abuse.

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Coulbourn Instruments

With more than 45 years’ experience in research instrumentation, Coulbourn Instruments and Panlab offer a comprehensive range of flexible and straightforward solutions for the automated evaluation of behavior in small laboratory animals. Quality and reliable tools for filling both standard and advanced needs in Neuroscience, Metabolism and Cardiovascular research: video-tracking, mazes, operant/behavior chambers, fear conditioning and startle test, rota rods, treadmills, indirect calorimetry and much more.

Harvard Bioscience, Inc.

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