Dr. Giacomo Rossitto shares his research on heart failure and the related lymphatic dysfunction in patients.
Excess tissue sodium, highly prevalent in cardiovascular disease, reflects clinical or subclinical extracellular volume expansion, a key and targetable determinant of disease. The generally neglected but highly sophisticated lymphatics serve as the major route for drainage of the fluids undergoing continuous extravasation toward the interstitium. In this webinar, Dr. Rossitto describes his physiological studies suggesting a defective interstitial fluid drainage in patients with heart failure, a prototypic condition for overt volume expansion. He also discusses recent evidence linking organ-specific lymphatic systems with organ function, with particular emphasis on the myocardium, the kidneys, and their interplay in the maintenance of fluid homeostasis.
Key Topics Include:
- Lymphatics are the major route for drainage of interstitial fluid
- Lymphatic function may impact body fluid homeostasis and organ function
- Better understanding of lymphatic biology holds great, largely unexplored potential for the treatment of cardiovascular disease
Assistant Professor, Consultant
Department of Medicine
Università degli Studi di Padova