Scientists discuss the use of NMR to analyze the antiviral drug Azidothymidine AZT, a medication currently used to prevent and treat HIV/AIDS.
Lead optimization in drug discovery has changed significantly during the last few years. Structural information on ligand-protein complexes, at atomic resolution, is considered to be extremely important to improve binding affinity. Moreover, the nature and energy of conformational changes of the free ligand in solution, can drive the binding recognition procedure, improving binding efficacy overall.
In this Bruker webinar, Dr. Armando Navarro will discuss the analysis of the antiviral drug Azidothymidine AZT (or Zidovudine ZDT). This compound is used as antiretroviral medication to prevent and treat HIV/AIDS and how to combine different NMR observables (NOE, J-couplings, chemical shifts…) for a more accurate conformational analysis.
Federal University of Pernambuco
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