Real-time IntraVital Microscopy (IVM): In Vivo Live Cell Imaging in Immunology and Neuroscience with Live Imaging Demo
Selina Soyeon Ahn, PhD will introduce IVIM Technology’s All-in-One real-time intravital confocal and two-photon microscopy system and its application to immunology and neuroscience research.
#ExpertAnswers: Nataliia Beztsinna and Marten Hornsveld on Pre-Clinical Immuno-Oncology
Nataliia Beztsinna and Marten Hornsveld describe how the tumor microenvironment modulates clinical responses and how patient-derived ex vivo and engineered in vitro models can be used for pre-clinical immuno-oncology testing.
What’s Next in Preclinical Cancer Immunotherapy Research?
Experts answers questions about key topics in the field of cancer immunotherapy, including new and emerging methods and future directions.
Cancer Immunotherapy: Viruses, Vaccines, and other Immuno-Oncology Treatments
In this blog post, current cancer immunotherapy treatments are discussed, as well as some future directions for this rapidly developing field.
Industry Insights with Crown Bioscience: Analyzing the Suppressive TME in In Vitro Based Assays
Nataliia Beztsinna and Marten Hornsveld from Crown Bioscience talk about native and reconstituted TME assays, how they can help in the preparation for clinical trials, and what kinds of therapies in development would benefit the most from this kind of testing.
Industry Insights with Crown Bioscience: Analyzing the Suppressive TME with In Vitro Based Assays
This episode of Industry Insights features Nataliia Beztsinna, PhD, and Marten Hornsveld, PhD, from Crown Bioscience as they describe how reconstituted TME and patient-derived ex vivo tissue assays can best be used within the drug development pipeline.
Brain-Derived Tau in Blood: the Future of Alzheimer’s Disease Diagnosis?
Recently published in Brain, Gonzalez-Ortiz et al. report the design and development of a novel blood-based biomarker specific to brain-derived tau. In this blog post, we dive into the advantages of their novel immunoassay over those that are commercially available, as well as its future implications for Alzheimer’s disease diagnosis.
Real-time IntraVital Microscopy (IVM): In Vivo Cellular-level Imaging of Internal Organs in a Live Animal
Join Pilhan Kim, PhD for an in-depth discussion on the All-in-One intravital two-photon and confocal microscopy system.
In Vivo Modeling of Immune-mediated Optic Neuropathies
Oliver W. Gramlich, PhD, answers the top questions from his webinar on the pathobiology and visual phenotype of immune-mediated optic neuropathies.
Industry Insights with Crown Bioscience: Targeting T Cells Within the Cancer-Immunity Cycle
In this episode of Industry Insights, Saskia De Man, PhD, Marrit Putker, PhD, and Pirouz Daftarian, PhD, from Crown Bioscience discuss assays and methods for evaluating T cell therapeutics, including organoids, co-cultures, and high content imaging.
Industry Insights with Crown Bioscience: Targeting T Cells Within the Cancer Immunity Cycle
Saskia De Man, Marrit Putker, and Pirouz Daftarian from Crown Bioscience discuss the impact of T cell-directed immunotherapy on the cancer-immunity cycle.
#ExpertAnswers: Marrit Putker, Saskia De Man, and Pirouz Daftarian on T Cell-Directed Immunotherapy
Marrit Putker, Saskia De Man, and Pirouz Daftarian from Crown Bioscience discuss T cell-directed immunotherapy on the cancer-immunity cycle, including mechanisms and targets capable of modulating and enhancing T cell activity and the application of methods and models including organoids and high content imaging.
#ExpertAnswers: Rajendra Kumari and Gera Goverse on the Cancer Immunity Cycle
Rajendra Kumari and Gera Goverse provide an overview of the cancer immunity cycle and present several methods, techniques, and model systems for immuno-oncology research.
#ExpertAnswers: Amy Sheng on Antibody Screening and Discovery
Amy Sheng provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody discovery.
Orphan Receptor GPR55: A New Therapeutic Target for Atherosclerosis?
Since the role of GPR55 in adaptive B cell response regulation has not yet been reported in the context of atherosclerosis, Guillamat-Prats et al. have investigated how GPR55 in B cells affects atherosclerosis development. In this blog post, we highlight the main findings from this study, which was published this month in Nature Cardiovascular Research.
Is DNA Vaccination the Future of Type 1 Diabetes Prevention and Management?
Given the fact that type 1 diabetes can vary considerably between individuals, a precision medicine-based therapeutic approach could revolutionize clinical care. Earlier this year, Postigo-Fernandez et al. evaluated a precision medicine approach to DNA vaccination in a mouse model of type 1 diabetes, which we review in this blog post.
Industry Insights with Crown Bioscience: In Vitro Technologies for Studying the Cancer-Immunity Cycle
In this episode of Industry Insights, Rajendra Kumari, PhD, and Gera Goverse, PhD, from Crown Bioscience answer questions about in vivo, in vitro, and ex vivo technologies and methods that can be used for immuno-oncology research along each step of the cancer-immunity cycle.
Industry Insights with Crown Bioscience: In Vitro Technologies for Studying the Cancer-Immunity Cycle
Rajendra Kumari and Gera Goverse from Crown Bioscience provide an overview of the cancer-immunity cycle and describe in vivo, in vitro, and ex vivo research tools to study immuno-oncology.
Industry Insights with Amy Sheng on Nanobodies
This episode of Share Science features Amy Sheng from Sino Biological, who shares how nanobodies are expected to revolutionize antibody-based drug therapies for a wide range of pathological conditions and especially cancer immunotherapy!
Clearing the Brain Fog: Long COVID and Cognitive Impairment
One common post-COVID symptom is brain fog or "COVID fog," which may affect up to 25% of recovered individuals. Given the global prevalence of SARS-CoV-2 and the detrimental impact of such cognitive impairment, the public health implications are considerable. Fernández-Castañeda et al. recently examined the underlying neurological changes associated with COVID fog, which we review in this blog post.
The Cancer-Immunity Cycle: Methods, Challenges, and Opportunities
In this series, experts provide an overview of technologies, techniques, challenges, and emerging research questions along each step of the cancer immunity cycle.
In Vivo Modeling of Immune-mediated Optic Neuropathies
Oliver W. Gramlich, PhD, provides an in-depth discussion about the pathobiology and visual phenotype of immune-mediated optic neuropathies.
Protocol Preview: Creating an Artificial Human Thymus in Mice
The majority of treatments for immunodeficiencies are temporary fixes, in part due to a lack of preclinical models that can accurately predict immune responses in humans. However, a novel model recently published in Nature Methods has potential to greatly improve future immune response studies, which we review in this blog post.
Optimizing CD34+ Cell Genome Editing for Efficiency and HSPC Maintenance
Experts answer questions about CD34+ cell gene editing, methods to evaluate genome editing efficiency, and optimal culture conditions to maintain HSPC function and long-term editing effects.
Analyzing the Suppressive TME in in Vitro Based Assays
Experts describe suppressive tumor immune microenvironment compartments and patient-derived tissue technologies capable of recapitulating the TME for clinically-relevant studies.
