Dr. Chad Deisenroth, PhD, from the US EPA, introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. Developed in collaboration with LifeNet Health, this model offers hormonogenic competence and the capacity to connect mechanistic insights with functional outcomes like thyroid hormone synthesis.
In this webinar, Dr. Deisenroth will discuss the US EPA Endocrine Disruptor Screening Program’s (EDSP) approach to screen chemicals for potential thyroid-disrupting effects and the urgent need to advance new approach methods that protect human health while reducing animal testing. He will showcase how hormone production in the model mimics human endocrine biology and is inhibited following exposure to known reference chemicals that affect key targets within the thyroid gland.
Dr. Deisenroth will also explain the methodology behind establishing minimum donor qualification criteria and benchmark parameters for test method standardization, transferability, and validation. This approach balances performance standardization with the ability to predict a range of human responses.
Lindsey Whaley from LifeNet Health will unveil the first primary human thyrocyte product that enables access to the 3D thyroid microtissue model. Join us for a journey into cutting-edge scientific research that promises to reshape how we assess thyroid disruption.
Key Topics Include:
- Development of the 3D thyroid microtissue model.
- Evaluation of model performance, including the production of thyroid hormone.
- Standardization of the model for thyroid disruption testing.
- Categories: Cell & Molecular Biology, Drug Discovery & Development, Pharmacology, Toxicology
- Tags: cell metabolism, drug development, drug discovery, drug metabolism, drug testing, drug-drug interaction, human biological sample (HBS), human cells, Mammalian cell culture, pharmacokinetics, pharmacology, safety pharmacology, toxicology
Presenters
Chad Deisenroth, PhD
Cell Biologist
Center for Computational Toxicology & Exposure
U.S. Environmental Protection Agency
Dr. Chad Deisenroth is a cell biologist in the Center for Computational Toxicology and Exposure at the U.S. EPA and has 14 years of experience in the development and application of in vitro new approach methods for predictive toxicology.
Lindsey Whaley, MS
Product Manager
LifeSciences
LifeNet Health
As LifeSciences product manager, Lindsey has a passion for driving innovation and delivering exceptional user experiences. Known for her collaborative approach and ability to translate marketing insights into actionable strategies, Lindsey is dedicated to delivering products that align with core customer needs. Lindsey holds a bachelor’s degree in biology and a master’s degree in biotechnology. During her academic journey, she completed two internships at LifeNet Health focused on various LifeSciences marketing projects where she quickly developed a passion for making high-quality, human research solutions accessible to scientific researchers. In her role as Product Manager for LifeNet Health LifeSciences, Lindsey collaborates with cross-functional teams to manage new product releases and an existing portfolio to a global market. She most enjoys using her scientific background to effectively communicate the benefits of LifeSciences’ innovation portfolio to the scientific community.
Production Partner
LifeNet Health LifeSciences
LifeNet Health LifeSciences leads the way in human in vitro biology for both non-diseased and diseased research needs. LifeNet Health LifeSciences combines innovative, technology-driven research and development programs to create human tissue and cell-based research products and services.
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