Dr. Sarah Stanley and Dr. Alexandra Alvarsson discuss the use of whole-organ imaging of the pancreas to reveal close interactions between nerves and islets and dynamic regulation of islet innervation in diabetes.
The pancreas is densely innervated, and neural signals play a significant role in glucose regulation by modulating pancreatic hormone release. However, relatively little is known about the anatomical relationships between islets and nerves across the whole pancreas. In this webinar, Dr. Sarah Stanley and Dr. Alexandra Alvarsson discuss their research using tissue clearing and whole organ imaging of the pancreas to identify the 3D structure of pancreatic nerves and islets.
In particular, they provide an overview of their methodology, which provides detailed information and quantification of pancreatic innervation in healthy pancreas, in canonical models of diabetes and in samples from nondiabetic and diabetic donors. They present their findings, demonstrating greatly enriched innervation in the islets with regional variations. They also discuss beta cell innervation in mouse models of diabetes and in pancreata from human donors with type 2 diabetes.
Key Topics Include:
- Tissue clearing and 3D imaging to allow the mapping of nerves in peripheral organs
- Innervation of peripheral organs such as the pancreas
- How pancreatic nerves are remodeled in diabetes
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Presenters
Assistant Professor
Diabetes, Obesity and Metabolism Institute
Icahn School of Medicine at Mount Sinai
Senior Scientist
Diabetes, Obesity and Metabolism Institute
Icahn School of Medicine at Mount Sinai