Join Dudley Lamming, PhD for a deep dive into his research involving how diets can affect metabolic health and longevity.
The population of the world is graying, but for many, living longer will not necessarily mean living in good health, and finding ways to promote healthy aging is critical. Here, Dudley will highlight recent and ongoing research into how quality, quantity, and timing of what we eat affects metabolic health, frailty, and longevity. First, he will use genetic mouse models to uncover the role of insulin sensitivity in the benefits of calorie restriction (CR), an intervention that extends the healthspan and lifespan of diverse species including mice. He will then dissect the role of calorie and collaterally imposed fasting on the benefits of a CR diet. Finally, he will examine how dietary levels of protein and the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine impact longevity. Our results demonstrate that what, when, and how much we eat have significant effects on metabolic health, fitness, and lifespan, and suggest that daily fasting or reducing dietary BCAAs may be a translatable intervention with the potential to promote healthy aging.
Key Topics Include:
- CR-induced improvements in insulin sensitivity are dispensable for the effects of CR on fitness and longevity
- A prolonged daily fast is necessary and sufficient for the effects of a CR diet on frailty and lifespan
- Restriction of dietary protein or BCAAs improves metabolic health
- Lifelong restriction of BCAAs extends the lifespan and healthspan of male, but not female, wild-type mice.
University of Wisconsin-Madison