Join Dr. Rizwan Qaisar and Matt Borkowski for a deep dive into the experimental protocols used for measuring muscle function and mechanics for in vivo and in vitro research.

The focus of this webinar is on the mechanisms underlying muscle impairment associated with aging and age-related diseases. This research evaluates the regulation of muscle contraction at the motor protein, single muscle fiber, and whole muscle levels using in vitroin situ and in vivo methods in experimental and clinical settings. Specifically, Dr. Qaisar is interested in the contribution(s) of muscle SR stress and calcium dysregulation to loss of muscle mass and strength. Reduced calcium uptake by muscle SR plays a pivotal role in muscle impairment in aging while boosting SR calcium uptake with pharmacological activators can partially restore muscle mass and strength. Matt will share a technical overview of the experimental equipment used in this research. He will discuss the design, component functionality, and that applications that can be explored with this system. He will also share some valuable insights into the parameters that can be measured and the data that can be produced with various experimental designs.

Key Topics Include:

  • Contractile dysfunction in sarcopenia involves alterations at motor protein, single fibers and whole muscle levels in rodent models of aging and elderly humans
  • Loss of calcium regulation by muscle SR plays a pivotal role in muscle atrophy and weakness associated with sarcopenia
  • Age-associated comorbidities such as COPD and Parkinson’s disease accelerated the sarcopenia phenotype in humans
  • Circulating biomarkers such as CAF22 can be useful predictors of muscle mass and strength in accelerated sarcopenia

Presenters

Assistant Professor
Basic Medical Sciences
College of Medicine, University of Sharjah, UAE

Dr. Qaisar earned his PhD from the University if Uppsala, Sweden and post-doctorates from the University of Pavia, Italy and Oklahoma Medical Research Foundation. His research work focuses on the pathophysiology and interventions of muscle impairment in sarcopenia in experimental and clinical settings.

Engineering Sales & Marketing Manager
Aurora Scientific Inc.

Matthew Borkowski is a biomedical engineer and a graduate of the University of Toronto. He has been involved in product design and customer support at Aurora Scientific for over 10 years.  Today, he spends much of his time in the lab consulting with scientists, assisting with novel application of Aurora Scientific instruments in various disciplines, including muscle, tendon, and connective tissue research.

Production Partner

Aurora Scientific, Inc.

Aurora Scientific supports the scientific community in its goal of research and discovery by providing precision instrumentation of the highest quality design, construction and functionality for Muscle Physiology, Material Science and Neuroscience applications.

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