Join Dr. Rizwan Qaisar and Matt Borkowski for a deep dive into the experimental protocols used for measuring muscle function and mechanics for in vivo and in vitro research.
The focus of this webinar is on the mechanisms underlying muscle impairment associated with aging and age-related diseases. This research evaluates the regulation of muscle contraction at the motor protein, single muscle fiber, and whole muscle levels using in vitro, in situ and in vivo methods in experimental and clinical settings. Specifically, Dr. Qaisar is interested in the contribution(s) of muscle SR stress and calcium dysregulation to loss of muscle mass and strength. Reduced calcium uptake by muscle SR plays a pivotal role in muscle impairment in aging while boosting SR calcium uptake with pharmacological activators can partially restore muscle mass and strength. Matt will share a technical overview of the experimental equipment used in this research. He will discuss the design, component functionality, and that applications that can be explored with this system. He will also share some valuable insights into the parameters that can be measured and the data that can be produced with various experimental designs.
Key Topics Include:
- Contractile dysfunction in sarcopenia involves alterations at motor protein, single fibers and whole muscle levels in rodent models of aging and elderly humans
- Loss of calcium regulation by muscle SR plays a pivotal role in muscle atrophy and weakness associated with sarcopenia
- Age-associated comorbidities such as COPD and Parkinson’s disease accelerated the sarcopenia phenotype in humans
- Circulating biomarkers such as CAF22 can be useful predictors of muscle mass and strength in accelerated sarcopenia
Basic Medical Sciences
College of Medicine, University of Sharjah, UAE
Engineering Sales & Marketing Manager
Aurora Scientific Inc.