Inflammation & Immunophysiology: An Exploration of PathophysiologyAndy Henton2021-04-14T14:43:49-04:00
Inflammation & Immunophysiology: An Exploration of Pathophysiology
The American Physiological Society (APS), American Autoimmune Related Diseases Association (AARDA), and InsideScientific are pleased to announce a joint webinar series covering fundamental principles, late-breaking research and novel discoveries in the field of inflammation and immunophysiology.
This program will include a number of live lectures, including top science from leading researchers around the world, and “Technology & Methods” sessions focused on laboratory innovations and fundamental methods central to immunology and inflammation research and related models of disease.
Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH)
Aging and Inflammation
Myeloid Cells and Cardiovascular Health
THU, MAY 13, 2021 – UPCOMING
Monocytes and macrophages are innate immune cells that reside and accumulate in atherosclerotic lesions but also in the healthy and injured heart and brain. The cells and their subsets pursue distinct functions in steady state and disease, and their tenure may range between hours to months. Some subsets are highly inflammatory, while others support tissue repair.
In this webinar, Dr. Matthias Nahrendorf will discuss current concepts of cell supply by the hematopoietic system, lineage relationships and systems’ cross talk, highlights open questions, and describes imaging tools for studying monocytes, macrophages and their progenitors.
Dr. Jerrold Turner is a physician-scientist who has made and continues to make contributions to our understanding of epithelial and mucosal biology and gastrointestinal pathophysiology and is an active as an educator, mentor, surgical pathologist, and leader. His interests are focused on how epithelia establish, maintain, and regulate barriers. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of his laboratory is to understand the biology of the tight junction. They take a multidisciplinary approach that integrates cell and developmental biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.
Mechanisms of Cancer Immunology & CAR T-Cell Therapy
THU, JUN 17, 2021 – UPCOMING
Genetically-modified T cell immunotherapy has achieved unprecedented responses in hematologic B cell malignancies, and there are now six different form of engineered T cells that have been modified with chimeric antigen receptors (CARs) that are FDA-approved for cancer.
In this webinar, Dr. Marcela Maus will discuss the components and technologies used in making a T cell product, some of the factors considered to be important for efficacy, and the underlying mechanisms of toxicity and resistance. She will also discuss the outlooks and recent data in development of CAR T cells and other forms of engineered T cells for solid tumors.
Marcela V. Maus, MD, PhD Associate Professor of Medicine, Harvard Medical School
Director of Cellular Immunotherapy, Mass General Cancer Center
Cardiovascular Diseases Associated with HIV and SARS-CoV-2 Infections
THU, SEP 9, 2021 – UPCOMING
Despite ongoing research around the world to better understand the pathogenesis of SARS-CoV-2, the ways in which it exacerbates cardiovascular disease (CVD) are not fully understood. While it is well accepted that SARS-CoV-2 infects lung epithelial cells, whether it can also infect endothelial cells is less clear.
In this webinar, Dr. Xuebin Qin will discuss his lab’s development and characterization of new rodent models of COVID-19, and how they use these models to study endothelial dysfunction and injury resulting from immune activation. Dr. Qin will also discuss why HIV infection is associated with increased risk of CVD. He will provide an overview of the cellular and molecular mechanisms underlying HIV-1-associated CVD, and the mouse and NHP models he has worked with to elucidate them.
Patients with systemic autoimmune diseases such as lupus and rheumatoid arthritis have a striking increase in risk to develop vascular complications such as myocardial infarction and stroke. Immune dysregulation characteristic of these diseases appears to play a prominent role in this enhanced risk.
In this presentation, Dr. Mariana Kaplan will highlight the role of the immune system in the development of vasculopathy and premature atherosclerosis in systemic autoimmunity and discuss potential strategies to prevent these devastating complications.
Regulation of Inflammation via Lymphatic Microvasculature
THU, NOV 11, 2021 – UPCOMING
An abstract summary is coming soon!
Dr. Gwendalyn Randolph’s laboratory considers the impact of how transit of cells and molecules out of tissues influences the inflammatory microenvironment. The lymphatic vasculature is the primary regulator of flux out of tissues and thus we focus on the functionality of the lymphatic vasculature as it relates to the transport of cargo, particularly myeloid antigen-presenting cells in immunity and molecular entities like HDL. In this context, they focus on two chronic inflammatory disease settings, experimental atherosclerosis and inflammatory bowel disease.
InsideScientific and The American Physiological Society welcome submissions from lab instrumentation manufacturers, service providers and CROs to plan and produce a “Technology & Methods” session for inclusion in our Inflammation & Immunophysiology Webinar Series.
These sessions must focus on experimental planning, lab methodology, and best-practices with a goal of audience education and improving research process and outcomes. The program will accommodate 6-8 Technology & Methods sessions, which will be assigned to industry partners on a first-come-first-served basis. Technology & Methods sessions will be 45 minutes in duration, structured as a 30 minute instructional lecture followed by a live Q&A with the audience.
Select sponsorship and program support packages will be available for the Inflammation & Immunophysiology Webinar Series.
Advertising and brand awareness packages will provide targeted exposure to registrants and webinar attendees. Again, a limited number of promotional packages are available for this program and will be confirmed on a first-come-first-served basis.