Dr. Gwendalyn Randolph’s laboratory considers the impact of how transit of cells and molecules out of tissues influences the inflammatory microenvironment. The lymphatic vasculature is the primary regulator of flux out of tissues and thus we focus on the functionality of the lymphatic vasculature as it relates to the transport of cargo, particularly myeloid antigen-presenting cells in immunity and molecular entities like HDL. In this context, they focus on two chronic inflammatory disease settings, experimental atherosclerosis and inflammatory bowel disease.