Brian Roche, PhD, DABT, DSP
Director of Safety Pharmacology
Charles River Laboratories
Dr. Roche received his doctorate in cardiovascular physiology from The Ohio State University in 2000, where he continued as a postdoctoral fellow until 2002. Dr. Roche worked in safety pharmacology at Quintiles QTest Labs and Battelle Memorial Institute before accepting the director of safety pharmacology position at WIL Research in 2014. Following the 2016 acquisition of WIL Research by Charles River, Dr. Roche has contributed to the scientific collaboration and establishment of best practices across all Charles River Laboratories’ safety pharmacology sites.
Throughout his career, Dr. Roche has focused on mechanistic follow-up studies to ICH S7A core battery to de-risk drugs in development, as well as supplemental studies to include renal, gastrointestinal and autonomic nervous systems. His research has included toxicological and pharmacological evaluations of compounds from early in vivo discovery/lead optimization through IND enabling studies. Dr. Roche’s extensive experience in cardiovascular, respiratory and central nervous system safety pharmacology research provides him with a unique ability to support both alignment of best practices and scientific innovation.