Dr. Matthew Caporizzo received his Bachelors degree in Engineering Physics from the University of Pittsburgh and his PhD under mentor Dr. Russell Composto in polymer physics and cell mechanics from the University of Pennsylvania. Dr. Caporizzo then trained under Dr. Yale Goldman in single molecule biophysics bulding an interferometric scattering microscope and developing an analytical Markov model to describe the molecular motility of processive dimers such as myosin motors.
In 2016, Matt received an American Heart Association Post-Doctoral Fellowship to join the lab of Dr. Benjamin Prosser and study the contribution of the microtubule cytoskeleton to cardiac viscoelasticity.There Matt pioneered new approaches to interrogate the passive viscoelasticity of cardiomyocytes and myocardium and developed a computational model which demonstrates that viscous resistance of the microtubule network is sufficient to inhibit the contraction of cardiomyocytes in heart failure. In 2021, Matt was awarded an American Heart Association Career Development Award to develop engineered cardiac tissues from human samples to interrogate the mechanical feedback between the microtubule cytoskeleton and the failing cardiac extracellular matrix.
In 2022 Matt was appointed as an Assistant Professor at the Larner College of Medicine at the University of Vermont where he is actively continuing his research on the molecular mechanisms that stiffen the failing heart and developing platforms to test new therapies that reverse pathological stiffening.