Dr. Mandeville received a PhD in nuclear physics from the University of Illinois in 1993 and has since worked at the Martinos Center for Biomedical Imaging at the Massachusetts General Hospital. His interest is the development, refinement, and characterization of neuroimaging methods. His early worked focused on functional MRI, particularly using exogenous contrast agents. His recent interests include simultaneous PET/fMRI applications that seek to provide an enhanced picture of neural function by correlating induced hemodynamic responses with neuroreceptor occupancy.