Experts present key considerations in the design of rigorous preclinical studies in rodent models of muscular dystrophy, including animal model selection, assays and endpoints, and how your results can inform translation to the clinic.
Suzie Buono discusses the work she and her team have done to provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
Jordan Fuqua discusses how autophagy and proteolytic processes are regulated in skeletal muscle, specifically looking at ULK1 and ULK2 and their roles in maintaining skeletal muscle homeostasis, morphology, protein aggregate degradation and autophagy.
Aaron Stupica and Keshari Thakali discuss techniques tissue bath myography and present a unique case study looking at the effect of maternal obesity on offspring perivascular adipose tissue and vascular function.
Building on its popular Biomechanics 101 Introduction, Noraxon turns it attention to the fundamental pillar of biomechanics: electromyography, or EMG. This informative session covers signal origin, acquisition, processing and analysis for a comprehensive and practical understanding of EMG research and assessment.