Category: Scientific Articles

  • Long COVID brain fog FI

Clearing the Brain Fog: Long COVID and Cognitive Impairment

News, Scientific Articles|

One common post-COVID symptom is brain fog or "COVID fog," which may affect up to 25% of recovered individuals. Given the global prevalence of SARS-CoV-2 and the detrimental impact of such cognitive impairment, the public health implications are considerable. Fernández-Castañeda et al. recently examined the underlying neurological changes associated with COVID fog, which we review in this blog post.

  • CrownBio Cancer-Immunity Cycle Blog FI

The Cancer-Immunity Cycle: Research Solutions for Preclinical Immuno-Oncology

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Cancer immunotherapy has undoubtedly expanded the cancer treatment landscape and improved patient outlook, which can in part be attributed to the recognition of the importance of the cancer-immunity cycle as a whole. In this blog, we provide an overview of the cancer-immunity cycle and highlight some preclinical models that can facilitate cancer immunotherapy research.

  • Passive Avoidance Response in Rats FI

Passive Avoidance Response in Rats: Effects of Handling and Novel Object Recognition

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Storing aversive memories is important to survival, but learned avoidance responses decrease over time without reinforcement. Since little is known about the mechanisms behind this process, Bengoetxea de Tena et al. evaluated how naive rats respond to a learning and memory task under fear conditions in a recently published study, which we review in this blog post.

  • HSV Skin-on-chip FI

Skin-on-Chip for Preclinical Herpes Disease Modeling

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Organs-on-a-chip are attractive alternatives for bridging the translational gap between preclinical and clinical stages in vaccine development, particularly for herpes simplex virus (HSV). In this blog post, we review an article from Nature Communications on a skin-on-chip device for modeling HSV infection, as well as evaluating immune responses and antiviral drug efficacy (featured image © 2022 Sun et al., licensed under CC BY 4.0).

  • Functional Ultrasound Neuroimaging

Functional Ultrasound: Pushing the Boundaries of Neuroimaging

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Although ultrasound has been used clinically for decades, advances in its temporal and spatial resolution have opened the door for its use in neuroscience research. In this blog post, we review a very recent and outstanding example of functional ultrasound neuroimaging published in Nature Methods in 2022 (featured image © 2022 Renaudin et al., licensed under CC BY 4.0).

Extracellular Vesicles as Breast Cancer Biomarkers

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Triple-negative breast cancer is particularly aggressive, challenging to treat, and accounts for 15-20% of all breast cancers. In this blog, we review a study published in Nature Communications that examines the transforming growth factor-β targetable signaling pathway, its role in malignant cancer progression and immune suppression, and tumor-derived extracellular vesicles as diagnostic and prognostic biomarkers.

  • Cancer cells

Combination Therapy for Cancer Treatment

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The combination of anti-cancer drugs, or combination therapy, has been hailed as a “cornerstone of cancer therapy” since it targets key pathways synergistically, thereby enhancing efficacy compared to monotherapies. This blog takes a look at a recent publication in Nature, which reported the effects of 2025 pairwise drug combinations in breast, colon, and pancreatic cell lines.

  • Exosome secretion from cells

Inhalable COVID-19 Vaccines: Recent Findings and Breakthroughs

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Given that SARS-CoV-2 is primarily transmitted through respiratory droplets, with respiratory mucosa being the main viral entry route, is intramuscular administration the most effective vaccine delivery method to fight COVID-19? In this blog post, we have reviewed one recent study that reported the design and preclinical testing of an inhalable, exosome-based COVID-19 vaccine.

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