Brain-Derived Tau in Blood: the Future of Alzheimer’s Disease Diagnosis?
Recently published in Brain, Gonzalez-Ortiz et al. report the design and development of a novel blood-based biomarker specific to brain-derived tau. In this blog post, we dive into the advantages of their novel immunoassay over those that are commercially available, as well as its future implications for Alzheimer’s disease diagnosis.
Novel Targets for Alzheimer’s Disease Treatment: Medin and PLD3
Given that Alzheimer's disease is multifactorial and heterogenous, drug development progress is more likely to occur if multiple pathways are considered. Two recent Nature publications have potentially identified medin and PLD3 as new targets for Alzheimer’s disease treatment, which we summarize in this mini-review.
#ExpertAnswers: Dennis Turner on the Metabolics of Dementia
Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models.
Strategic Approaches to Age-Related Metabolic Insufficiency and Transition into Dementia Syndrome
In this webinar, Dr. Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models.
Alzheimer’s Disease: Recent Research & Therapeutic Advances
A review of Alzheimer's disease pathology, conventional treatments and their limitations, as well as emerging and potential therapies including monoclonal antibodies, metabolic therapies, and stem cell therapies.
#ExpertAnswers: Ashley Walker on Alzheimer’s Disease
Ashley Walker discusses her research on the vascular contributions to late-onset Alzheimer’s disease.
Vascular Contributions to Dementia
Ashley Walker, PhD discusses her research on the vascular contributions to late-onset Alzheimer’s disease and dementia.
Cardiovascular Connections: An Integrative Approach
Cardiovascular Connections: An Integrative Approach - A webinar series covering fundamentals, late-breaking research and novel discoveries in the field of cardiovascular science.
#ExpertAnswers: Agenor Limon on the Electrophysiology of Human Native Receptors
Agenor Limon discusses reactivation and microtransplantation of synaptic receptors from frozen human brain samples into xenopus oocytes to evaluate the relationship between synaptic activity and behavioral abnormalities.
Electrophysiology of Human Native Receptors in Neurological and Mental Disorders
Dr. Agenor Limon presents research integrating functional metrics with large anatomical, transcriptomic, and proteomic datasets to evaluate the relationship between synaptic E/I ratio and behavioral abnormalities across postmortem intervals and brain banks.
#ExpertAnswers: Joanna Hummer and Florie Le Prieult on cOFM for in vivo Cerebral Fluid Sampling
Experts discuss cerebral open flow microperfusions use, and honing in specifically on its use in drug development and neurodegenerative disease.
Cerebral Open Flow Microperfusion (cOFM) for in vivo Cerebral Fluid Sampling – Comparison of cOFM and Microdialysis
Dr. Joanna Hummer and Dr. Florie Le Prieult share insights into cOFM's use and utility in the broader neuroscience field and specifically for the development of drugs for neurodegenerative diseases.
#ExpertAnswers: Rohan Jagirdar on Sleep and Alzheimer’s Disease
In this episode of #ExpertAnswers join Rohan Jagirdar, PhD, from Baylor College of Medicine, as he answers questions from a [...]
#ExpertAnswers: Fiona Harrison on Early Alzheimer’s Disease
Dr. Fiona Harrison, discusses how vitamin C deficiency and exposure to toxins can impact glutamate uptake and clearance, and how even small changes in neural signaling can be detected by monitoring EEG activity and correlated with performance in learning and memory tasks.
Improving Sleep to Slow the Progression of Alzheimer’s Disease
Join Rohan Jagirdar, PhD as he discusses his research on EEG activity in a mouse model of Alzheimer's disease to determine the effects of improved sleep on disease progression.
EEG Monitoring Approaches to Predict Learning and Memory Changes in Early Alzheimer’s Disease
Dr. Fiona Harrison discusses how dietary deficiency and exposure to toxins can impact glutamate uptake and clearance, and the subsequent changes in neural signaling can be detected through altered EEG activity and performance on learning and memory tasks.
Malignant Brain Aging: The Formidable Link to Neurodegeneration
Dr. De La Monte discusses her research involving the roles of brain insulin deficiency and insulin resistance in Alzheimer's disease.
Alzheimer’s & Brain Awareness Month 2020
Image source: Alzheimer’s Association @alzassociation June is Alzheimer’s and Brain Awareness Month! At InsideScientific, we are proud to [...]
#ExpertAnswers: John Cirrito & Candace Rhode-Johnson on Micro-dialysis and Neuroscience
In this episode of Expert Answers, John Cirrito and Candace Rhode-Johnson discuss the use of a novel movement responsive rodent caging system.
Turn Away from Traditional Tethering and Towards a Better Method for Data Collection
Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.
In Vivo Research Approaches in the Study of Neurological Disease and Psychiatric Disorders
According to the WHO, 1 in 4 people will be affected by mental illness or a neurological disorder at [...]
The Cutting Edge of Animal Behavioral Neuroscience
Since Dr. Ivan Pavlov studied dogs in the 19th century, behavioral science has come a very long way. Novel [...]
JUNE is Alzheimer’s and Brain Awareness Month!
Worldwide, more than 50 million people are living with Alzheimer’s Disease and other dementias. This month, you can join the [...]
#ExpertAnswers: Marco Weiergräber and Jennifer Teske on Measuring Sleep with EEG
Marco Weiergräber and Jennifer Teske discuss case studies highlighting the use of small animal EEG telemetry for measuring REM and non-REM sleep in rats, as well as hippocampal theta oscillations in a mouse model of Alzheimers.
Measuring EEG in vivo for Preclinical Evaluation of Sleep and Alzheimer’s Disease
Experts present telemetry implant procedure for wireless recording of EEG in rodents and share novel case studies focused on studying neural recordings to investigate sleep, energy expenditure and Alzheimer's Disease.
