From Trauma to Binge Eating: How Early Life Experiences Impact the Leptin System
Early life trauma (ELT) has been identified as a risk factor for binge eating and obesity in adult life, but the neural mechanisms behind this phenomena have yet to be determined. In this blog post we discuss a recent publication from Shin et al., which delineates the circuitry of this ELT-induced maladaptive eating.
What’s Next in Preclinical Cancer Immunotherapy Research?
Experts answers questions about key topics in the field of cancer immunotherapy, including new and emerging methods and future directions.
A Breath of Not-So-Fresh Air: the Combined Effects of Air and Noise Pollution
While air and noise pollution have been well documented independently, their combined effects are insufficiently discussed, until recently. In this blog post, we discuss a recent publication from Kuntic et al. on the combined and individual effects of these pollutants in mice.
Leveraging Programmable CRISPR-Associated Transposases for Next-Generation Genome Engineering
Dr. Sam Sternberg discusses a novel CRISPR-Cas9 system using programmable, RNA-guided transposase, and highlights its implications for kilobase-scale genome engineering in cell and gene therapies.
Synthetic Peptide Growth Factors: Forging the Path Forward for Regenerative Medicine, Cell Therapy, and Cellular Agriculture
Experts discuss how synthetic growth factors work and share application examples and data using these synthetic peptides for cell therapy and regenerative medicine.
Cancer Immunotherapy: Viruses, Vaccines, and other Immuno-Oncology Treatments
In this blog post, current cancer immunotherapy treatments are discussed, as well as some future directions for this rapidly developing field.
Celebrating Black Scientists: 5 Scientific Stories from the Past
In honor of Black History Month, this blog discusses 5 scientific stories from some historic Black and African-American scientists, researchers, and medical professionals.
Industry Insights with Crown Bioscience: Analyzing the Suppressive TME in In Vitro Based Assays
Nataliia Beztsinna and Marten Hornsveld from Crown Bioscience talk about native and reconstituted TME assays, how they can help in the preparation for clinical trials, and what kinds of therapies in development would benefit the most from this kind of testing.
Industry Insights with Crown Bioscience: Analyzing the Suppressive TME with In Vitro Based Assays
This episode of Industry Insights features Nataliia Beztsinna, PhD, and Marten Hornsveld, PhD, from Crown Bioscience as they describe how reconstituted TME and patient-derived ex vivo tissue assays can best be used within the drug development pipeline.
Protocol Preview: Long-read sequencing, Nature’s Method of the Year
Nature Methods declared "Long-Read Sequencing" their Method of the Year for 2022, but what exactly makes this technique worthy of such a title?
The 3D DILI Model of Success – from Biological Relevance to Industry Application
Experts from InSphero answer questions about the application of their 3D human liver microtissues for drug induced liver injury (DILI) experiments.
The Blues & the Browns: Links between Depression and Gut Microbiota
Recently, Radjabzadeh et al., identified 13 genera of gut microbiota that have been implicated with symptoms of depression.
Rethink Your Impurity Analysis Strategy
In this webinar, Dr. Ejvind Mørtz discusses the benefits and applications of mass spectrometry (MS)-based host cell protein (HCP) analysis and why HCP ELISAs are insufficient for documenting product-related impurities. Watch to learn where to apply the assay in a typical process and what you gain from deploying it to your workflow.
Functional Recovery of the Musculoskeletal System Following Injury – Leveraging the Large Animal Model
Sarah Greising, PhD answers top questions from her recent webinar focused on the pathophysiologic understanding of the skeletal muscle remaining following traumatic musculoskeletal injuries, specifically in large animal models.
Real-time IntraVital Microscopy (IVM): In Vivo Cellular-level Imaging of Internal Organs in a Live Animal
Join Pilhan Kim, PhD for an in-depth discussion on the All-in-One intravital two-photon and confocal microscopy system.
The 3D DILI Model of Success – from Biological Relevance to Industry Application
Dr. Anna Borgström and Dr. Frauke Greve present the latest advancements in hepatic safety assessment using 3D liver spheroids.
Cardiovascular Regenerative Medicine: Deconstructing Regenerative Therapeutics
Eduardo Marbán, MD, PhD, answers the top questions from his webinar on the complexities of regenerative cardiovascular medicine and the future directions for cell therapies.
Cardiac Tissue Slices: Preparation, Data Acquisition, and Analysis
Bradley Palmer, PhD, answers top questions from a recent webinar on the challenging preparation of cardiac tissue slices and measurement of force and calcium.
#ExpertAnswers: Audrey Dubourg and Gareth Guenigault on the Organ-On-A-Chip Approach
Audrey Dubourg and Gareth Guenigault from CN Bio discuss the value that an organ-on-a-chip approach can bring to drug discovery and development workflows, and how the regulatory landscape is shifting to encourage their widespread adoption.
It’s Life, but Not As We Know It: How Predictive Human Organ Models Are Transforming and Reshaping the Efficiency of Drug Discovery
Experts answer questions about the application of organ-on-a-chip technology for preclinical drug discovery research.
Protocol Preview: In Vivo Gene Therapy Using Peptide-Based Delivery
Although gene therapy has been in discussion for decades, its translation to clinical practice has been a slow and challenging process. As a solution to this translational challenge, Allen et al. have proposed a peptide-based delivery method of Cre recombinase for in vivo gene therapy, which we review in this blog post.
Industry Insights with Crown Bioscience: Targeting T Cells Within the Cancer Immunity Cycle
Saskia De Man, Marrit Putker, and Pirouz Daftarian from Crown Bioscience discuss the impact of T cell-directed immunotherapy on the cancer-immunity cycle.
#ExpertAnswers: Marrit Putker, Saskia De Man, and Pirouz Daftarian on T Cell-Directed Immunotherapy
Marrit Putker, Saskia De Man, and Pirouz Daftarian from Crown Bioscience discuss T cell-directed immunotherapy on the cancer-immunity cycle, including mechanisms and targets capable of modulating and enhancing T cell activity and the application of methods and models including organoids and high content imaging.
Novel Targets for Alzheimer’s Disease Treatment: Medin and PLD3
Given that Alzheimer's disease is multifactorial and heterogenous, drug development progress is more likely to occur if multiple pathways are considered. Two recent Nature publications have potentially identified medin and PLD3 as new targets for Alzheimer’s disease treatment, which we summarize in this mini-review.
#ExpertAnswers: Dudley Lamming on the Influence of Sex and Genetic Background on Diet
Dudley Lamming, PhD, explains that “We Are More Than What We Eat”; Sex and Genetic background are important factors in observing responses to diet in mice.